Investigation of Effects of Local Vitamin C Application on Inflammatory Response and Periodontal Tissue Destruction in Rat Periodontitis Model

Background: The present study aims to evaluate the effect of local vitamin C application on inflammatory response and periodontal tissue destruction in rats with experimental periodontitis.
 Methods: A total 21 animals, 7 each group, were used study: 1- Non-ligation (NL), 2-experimental periodontitis (EP), 3- (VtC) groups. Experimental was induced EP VtC group rats. After 11 days, ligature removed. 50 mL saline solution injected locally into vestibule sulcus rats, respectively. sacrificed, blood gingival samples taken. TNF-α levels analyzed biochemically serum 8-OHdG MMP-8 immunohistochemically tissue. mandibular specimens histologically evaluated for bone attachment loss.
 Results: numeric density immunopositive cells found be statistically significantly lower Vtc than group. Vitamin administration reduced loss as compared However, there no significant difference level group.
 Conclusions: Local may reduce inflammation-related by supporting antioxidant activity contributing resolution inflammation its potential immunomodulatory effect. a therapeutic agent that can treatment periodontitis.